Humanity has wondered whether we are alone for millennia. The discovery of life elsewhere in the Universe, particularly intelligent life, would have profound effects, comparable to those of recognizing that the Earth is not the center of the Universe and that humans evolved from previous species. There has been rapid growth in the fields of extrasolar planets and data-driven astronomy. In a relatively short interval, we have seen a change from knowing of no extrasolar planets to now knowing more potentially habitable extrasolar planets than there are planets in the Solar System. In approximately the same interval, astronomy has transitioned to a field in which sky surveys can generate 1 PB or more of data. The Data-Driven Approaches to Searches for the Technosignatures of Advanced Civilizations_ study at the W. M. Keck Institute for Space Studies was intended to revisit searches for evidence of alien technologies in light of these developments. Data-driven searches, being able to process volumes of data much greater than a human could, and in a reproducible manner, can identify anomalies that could be clues to the presence of technosignatures. A key outcome of this workshop was that technosignature searches should be conducted in a manner consistent with Freeman Dyson’s arcsecFirst Law of SETI Investigations, arcsec namely arcsecevery search for alien civilizations should be planned to give interesting results even when no aliens are discovered. arcsec This approach to technosignatures is commensurate with NASA’s approach to biosignatures in that no single observation or measurement can be taken as providing full certainty for the detection of life. Areas of particular promise identified during the workshop were () Data Mining of Large Sky Surveys, () All-Sky Survey at Far-Infrared Wavelengths, () Surveys with Radio Astronomical Interferometers, and () Artifacts in the Solar System.